2iy9

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{{Seed}}
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{{STRUCTURE_2iy9| PDB=2iy9 | SCENE= }}
{{STRUCTURE_2iy9| PDB=2iy9 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE A-SUBUNIT OF THE AB5 TOXIN FROM E. COLI'''
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===CRYSTAL STRUCTURE OF THE A-SUBUNIT OF THE AB5 TOXIN FROM E. COLI===
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==Overview==
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AB5 toxins are produced by pathogenic bacteria and consist of enzymatic A subunits that corrupt essential eukaryotic cell functions, and pentameric B subunits that mediate uptake into the target cell. AB5 toxins include the Shiga, cholera and pertussis toxins and a recently discovered fourth family, subtilase cytotoxin, which is produced by certain Shiga toxigenic strains of Escherichia coli. Here we show that the extreme cytotoxicity of this toxin for eukaryotic cells is due to a specific single-site cleavage of the essential endoplasmic reticulum chaperone BiP/GRP78. The A subunit is a subtilase-like serine protease; structural studies revealed an unusually deep active-site cleft, which accounts for its exquisite substrate specificity. A single amino-acid substitution in the BiP target site prevented cleavage, and co-expression of this resistant protein protected transfected cells against the toxin. BiP is a master regulator of endoplasmic reticulum function, and its cleavage by subtilase cytotoxin represents a previously unknown trigger for cell death.
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(as it appears on PubMed at http://www.pubmed.gov), where 17024087 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17024087}}
==About this Structure==
==About this Structure==
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[[Category: Shiga]]
[[Category: Shiga]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:04:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:54:42 2008''

Revision as of 12:54, 29 July 2008

Image:2iy9.png

Template:STRUCTURE 2iy9

CRYSTAL STRUCTURE OF THE A-SUBUNIT OF THE AB5 TOXIN FROM E. COLI

Template:ABSTRACT PUBMED 17024087

About this Structure

2IY9 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP., Paton AW, Beddoe T, Thorpe CM, Whisstock JC, Wilce MC, Rossjohn J, Talbot UM, Paton JC, Nature. 2006 Oct 5;443(7111):548-52. PMID:17024087

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