2f01

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[[Image:2f01.gif|left|200px]]
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{{STRUCTURE_2f01| PDB=2f01 | SCENE= }}
{{STRUCTURE_2f01| PDB=2f01 | SCENE= }}
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'''Epi-biotin complex with core streptavidin'''
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===Epi-biotin complex with core streptavidin===
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==Overview==
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(+)-Epi-biotin differs from (+)-biotin in the configuration of the chiral center at atom C2. This could lead to a difference in the mode of binding of (+)-epi-biotin to streptavidin, a natural protein receptor for (+)-biotin. Diffraction data were collected to a maximum of 0.85 Angstrom resolution for structural analysis of the complex of streptavidin with a sample of (+)-epi-biotin and refinement was carried out at both 1.0 and 0.85 Angstrom resolution. The structure determination shows a superposition of two ligands in the binding site, (+)-biotin and (+)-epi-biotin. The molecules overlap in the model for the complex except for the position of S1 in the tetrahydrothiophene ring. Differences in the conformation of the ring permits binding of each molecule to streptavidin with little observable difference in the protein structures at this high resolution.
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(as it appears on PubMed at http://www.pubmed.gov), where 16699183 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16699183}}
==About this Structure==
==About this Structure==
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[[Category: Protein/ligand interaction]]
[[Category: Protein/ligand interaction]]
[[Category: Streptavidin]]
[[Category: Streptavidin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:18:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:56:01 2008''

Revision as of 12:56, 29 July 2008

Image:2f01.png

Template:STRUCTURE 2f01

Epi-biotin complex with core streptavidin

Template:ABSTRACT PUBMED 16699183

About this Structure

2F01 is a Single protein structure of sequence from Streptomyces avidinii. Full crystallographic information is available from OCA.

Reference

The high-resolution structure of (+)-epi-biotin bound to streptavidin., Le Trong I, Aubert DG, Thomas NR, Stenkamp RE, Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):576-81. Epub 2006, May 12. PMID:16699183

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