1q0y

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[[Image:1q0y.gif|left|200px]]
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{{Seed}}
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[[Image:1q0y.png|left|200px]]
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{{STRUCTURE_1q0y| PDB=1q0y | SCENE= }}
{{STRUCTURE_1q0y| PDB=1q0y | SCENE= }}
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'''Anti-Morphine Antibody 9B1 Complexed with Morphine'''
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===Anti-Morphine Antibody 9B1 Complexed with Morphine===
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==Overview==
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The crystal structures of an anti-morphine antibody 9B1 (to 1.6A resolution) and its complex with morphine (to 2.0 A resolution) are reported. The morphine-binding site is described as a shallow depression on the protein surface, an unusual topology for a high-affinity ( Ka approximately 10(9) M(-1)) antibody against a small antigen. The polar part of the ligand is exposed to solvent, and the cationic nitrogen atom of the morphine molecule is anchored at the bottom of the binding site by a salt-bridge to a glutamate side-chain. Additional affinity is provided by a double cation-pi interaction with two tryptophan residues. Comparison of the morphine complex with the structure of the free Fab shows that a domain closure occurs upon binding of the ligand.
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The line below this paragraph, {{ABSTRACT_PUBMED_15019787}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15019787 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15019787}}
==About this Structure==
==About this Structure==
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[[Category: Anti-morphine antibody]]
[[Category: Anti-morphine antibody]]
[[Category: Fab]]
[[Category: Fab]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:43:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:00:37 2008''

Revision as of 13:00, 29 July 2008

Image:1q0y.png

Template:STRUCTURE 1q0y

Anti-Morphine Antibody 9B1 Complexed with Morphine

Template:ABSTRACT PUBMED 15019787

About this Structure

1Q0Y is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Anchoring a cationic ligand: the structure of the Fab fragment of the anti-morphine antibody 9B1 and its complex with morphine., Pozharski E, Wilson MA, Hewagama A, Shanafelt AB, Petsko G, Ringe D, J Mol Biol. 2004 Mar 26;337(3):691-7. PMID:15019787

Page seeded by OCA on Tue Jul 29 16:00:37 2008

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