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1vqa

From Proteopedia

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[[Image:1vqa.jpg|left|200px]]
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{{Seed}}
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[[Image:1vqa.png|left|200px]]
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{{STRUCTURE_1vqa| PDB=1vqa | SCENE= }}
{{STRUCTURE_1vqa| PDB=1vqa | SCENE= }}
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'''GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ALA 35 AND ILE 47 REPLACED BY LEU 47 (V35A, I47L)'''
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===GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ALA 35 AND ILE 47 REPLACED BY LEU 47 (V35A, I47L)===
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==Overview==
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The problem of rationally engineering protein molecules can be simplified where effects of mutations on protein function are additive. Crystal structures of single and double mutants in the hydrophobic core of gene V protein indicate that structural and functional effects of core mutations are additive when the regions structurally influenced by the mutations do not substantially overlap. These regions of influence can provide a simple basis for identifying sets of mutations that will show additive effects.
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(as it appears on PubMed at http://www.pubmed.gov), where 8855252 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8855252}}
==About this Structure==
==About this Structure==
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[[Category: Gene v]]
[[Category: Gene v]]
[[Category: Mutant]]
[[Category: Mutant]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:47:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:01:36 2008''

Revision as of 13:01, 29 July 2008

Image:1vqa.png

Template:STRUCTURE 1vqa

GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ALA 35 AND ILE 47 REPLACED BY LEU 47 (V35A, I47L)

Template:ABSTRACT PUBMED 8855252

About this Structure

1VQA is a Single protein structure of sequence from Enterobacteria phage f1. Full crystallographic information is available from OCA.

Reference

Potential use of additivity of mutational effects in simplifying protein engineering., Skinner MM, Terwilliger TC, Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10753-7. PMID:8855252

Page seeded by OCA on Tue Jul 29 16:01:36 2008

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