1ngt

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{{STRUCTURE_1ngt| PDB=1ngt | SCENE= }}
{{STRUCTURE_1ngt| PDB=1ngt | SCENE= }}
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'''The Role of Minor Groove Functional Groups in DNA Hydration'''
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===The Role of Minor Groove Functional Groups in DNA Hydration===
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==Overview==
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Here we describe the crystal structure of modified [d(CGCGAATTCGCG)]2 refined to 2.04 A. The modification, which affects only the two thymines at the central ApT step, involves isosteric removal of the 2-keto oxygen atoms and substitution of the N1 nitrogen with carbon. The crystal structure reveals the ability of this modified thymine to effectively base pair with adenine in [d(CGCGAAtTCGCG)]2. The structure also suggests that the minor groove 'spine of hydration' is destabilized but essentially intact.
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(as it appears on PubMed at http://www.pubmed.gov), where 12595562 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12595562}}
==About this Structure==
==About this Structure==
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[[Category: Modified base]]
[[Category: Modified base]]
[[Category: Spine of hydration]]
[[Category: Spine of hydration]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:30:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:07:02 2008''

Revision as of 13:07, 29 July 2008

Image:1ngt.png

Template:STRUCTURE 1ngt

The Role of Minor Groove Functional Groups in DNA Hydration

Template:ABSTRACT PUBMED 12595562

About this Structure

Full crystallographic information is available from OCA.

Reference

The role of minor groove functional groups in DNA hydration., Woods KK, Lan T, McLaughlin LW, Williams LD, Nucleic Acids Res. 2003 Mar 1;31(5):1536-40. PMID:12595562

Page seeded by OCA on Tue Jul 29 16:07:02 2008

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