3b5d

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{{STRUCTURE_3b5d| PDB=3b5d | SCENE= }}
{{STRUCTURE_3b5d| PDB=3b5d | SCENE= }}
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'''EmrE multidrug transporter in complex with TPP, C2 crystal form'''
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===EmrE multidrug transporter in complex with TPP, C2 crystal form===
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==Overview==
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EmrE, a multidrug transporter from Escherichia coli, functions as a homodimer of a small four-transmembrane protein. The membrane insertion topology of the two monomers is controversial. Although the EmrE protein was reported to have a unique orientation in the membrane, models based on electron microscopy and now defunct x-ray structures, as well as recent biochemical studies, posit an antiparallel dimer. We have now reanalyzed our x-ray data on EmrE. The corrected structures in complex with a transport substrate are highly similar to the electron microscopy structure. The first three transmembrane helices from each monomer surround the substrate binding chamber, whereas the fourth helices participate only in dimer formation. Selenomethionine markers clearly indicate an antiparallel orientation for the monomers, supporting a "dual topology" model.
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(as it appears on PubMed at http://www.pubmed.gov), where 18024586 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18024586}}
==About this Structure==
==About this Structure==
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[[Category: Smr]]
[[Category: Smr]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:24:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:08:54 2008''

Revision as of 13:09, 29 July 2008

Image:3b5d.png

Template:STRUCTURE 3b5d

EmrE multidrug transporter in complex with TPP, C2 crystal form

Template:ABSTRACT PUBMED 18024586

About this Structure

3B5D is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

X-ray structure of EmrE supports dual topology model., Chen YJ, Pornillos O, Lieu S, Ma C, Chen AP, Chang G, Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18999-9004. Epub 2007 Nov, 16. PMID:18024586

Page seeded by OCA on Tue Jul 29 16:08:54 2008

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