1pbw

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{{STRUCTURE_1pbw| PDB=1pbw | SCENE= }}
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'''STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN'''
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===STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN===
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==Overview==
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Proteins such as the product of the break-point cluster region, chimaerin, and the Src homology 3-binding protein 3BP1, are GTPase activating proteins (GAPs) for members of the Rho subfamily of small GTP-binding proteins (G proteins or GTPases). A 200-residue region, named the breakpoint cluster region-homology (BH) domain, is responsible for the GAP activity. We describe here the crystal structure of the BH domain from the p85 subunit of phosphatidylinositol 3-kinase at 2.0 A resolution. The domain is composed of seven helices, having a previously unobserved arrangement. A core of four helices contains most residues that are conserved in the BH family. Their packing suggests the location of a G-protein binding site. This structure of a GAP-like domain for small GTP-binding proteins provides a framework for analyzing the function of this class of molecules.
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{{ABSTRACT_PUBMED_8962058}}
==About this Structure==
==About this Structure==
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[[Category: Signal transduction]]
[[Category: Signal transduction]]
[[Category: Tpase activating protein]]
[[Category: Tpase activating protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:55:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:09:23 2008''

Revision as of 13:09, 29 July 2008

Image:1pbw.png

Template:STRUCTURE 1pbw

STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN

Template:ABSTRACT PUBMED 8962058

About this Structure

1PBW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit., Musacchio A, Cantley LC, Harrison SC, Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14373-8. PMID:8962058

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