2arj

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{{STRUCTURE_2arj| PDB=2arj | SCENE= }}
{{STRUCTURE_2arj| PDB=2arj | SCENE= }}
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'''CD8alpha-alpha in complex with YTS 105.18 Fab'''
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===CD8alpha-alpha in complex with YTS 105.18 Fab===
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==Overview==
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The CD8 glycoprotein functions as an essential element in the control of T-cell selection, maturation and the TCR-mediated response to peptide antigen. CD8 is expressed as both heterodimeric CD8alphabeta and homodimeric CD8alphaalpha isoforms, which have distinct physiological roles and exhibit tissue-specific expression patterns. CD8alphaalpha has previously been crystallized in complex with class I pMHC and, more recently, with the mouse class Ib thymic leukemia antigen (TL). Here, we present the crystal structure of a soluble form of mouse CD8alphaalpha in complex with rat monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolution. YTS 105.18, which is commonly used in the blockade of CD8+ T-cell activation in response to peptide antigen, is specific for mouse CD8alpha. The YTS 105.18 Fab is one of only five rat IgG Fab structures to have been reported to date. Analysis of the YTS 105.18 Fab epitope on CD8alpha reveals that this antibody blocks CD8 activity by hydrogen bonding to residues that are critical for interaction with both class I pMHC and TL. Structural comparison of the liganded and unliganded forms of soluble CD8alphaalpha indicates that the mouse CD8alphaalpha immunoglobulin-domain dimer does not undergo significant structural alteration upon interaction either with class I pMHC or TL.
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(as it appears on PubMed at http://www.pubmed.gov), where 16530222 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16530222}}
==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin domain]]
[[Category: Immunoglobulin domain]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:23:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:12:20 2008''

Revision as of 13:12, 29 July 2008

Image:2arj.png

Template:STRUCTURE 2arj

CD8alpha-alpha in complex with YTS 105.18 Fab

Template:ABSTRACT PUBMED 16530222

About this Structure

2ARJ is a Single protein structure of sequence from Mus musculus and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the TCR co-receptor CD8alphaalpha in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolution., Shore DA, Teyton L, Dwek RA, Rudd PM, Wilson IA, J Mol Biol. 2006 Apr 28;358(2):347-54. Epub 2006 Feb 23. PMID:16530222

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