1tlw

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{{STRUCTURE_1tlw| PDB=1tlw | SCENE= }}
{{STRUCTURE_1tlw| PDB=1tlw | SCENE= }}
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'''Tsx structure complexed with thymidine'''
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===Tsx structure complexed with thymidine===
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==Overview==
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Tsx is a nucleoside-specific outer membrane (OM) transporter of Gram-negative bacteria. We present crystal structures of Escherichia coli Tsx in the absence and presence of nucleosides. These structures provide a mechanism for nucleoside transport across the bacterial OM. Tsx forms a monomeric, 12-stranded beta-barrel with a long and narrow channel spanning the outer membrane. The channel, which is shaped like a keyhole, contains several distinct nucleoside-binding sites, two of which are well defined. The base moiety of the nucleoside is located in the narrow part of the keyhole, while the sugar occupies the wider opening. Pairs of aromatic residues and flanking ionizable residues are involved in nucleoside binding. Nucleoside transport presumably occurs by diffusion from one binding site to the next.
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{{ABSTRACT_PUBMED_15272310}}
==About this Structure==
==About this Structure==
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[[Category: Nucleoside transporter]]
[[Category: Nucleoside transporter]]
[[Category: Thymidine]]
[[Category: Thymidine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:06:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:13:36 2008''

Revision as of 13:13, 29 July 2008

Image:1tlw.png

Template:STRUCTURE 1tlw

Tsx structure complexed with thymidine

Template:ABSTRACT PUBMED 15272310

About this Structure

1TLW is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the bacterial nucleoside transporter Tsx., Ye J, van den Berg B, EMBO J. 2004 Aug 18;23(16):3187-95. Epub 2004 Jul 22. PMID:15272310

Page seeded by OCA on Tue Jul 29 16:13:36 2008

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