1rl3

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[[Image:1rl3.gif|left|200px]]
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{{STRUCTURE_1rl3| PDB=1rl3 | SCENE= }}
{{STRUCTURE_1rl3| PDB=1rl3 | SCENE= }}
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'''Crystal structure of cAMP-free R1a subunit of PKA'''
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===Crystal structure of cAMP-free R1a subunit of PKA===
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==Overview==
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In eukaryotes the primary target for cAMP, a ubiquitous second messenger, is cAMP-dependent protein kinase (PKA). Understanding how binding and release of cAMP changes the cAMP binding domains and then triggers long-range allosteric responses is an important challenge. This conformational switching requires structure solutions of cAMP binding domains in cAMP-bound and cAMP-free states. We describe for the first time a crystal structure of the cAMP binding domains of PKA type Ialpha regulatory subunit where site A is occupied by cGMP and site B is unoccupied. The structure reveals that the carboxyl terminus of domain B serves as a hydrophobic cap, locking the cyclic nucleotide via its adenine ring into the beta-barrel. In the absence of cAMP, the "cap" is released via an extension of the C-terminal helix. This simple hinge mechanism for binding and release of cAMP also provides a mechanism for allosteric communication between sites A and B.
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The line below this paragraph, {{ABSTRACT_PUBMED_15274925}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15274925 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15274925}}
==About this Structure==
==About this Structure==
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[[Category: Crystal structure]]
[[Category: Crystal structure]]
[[Category: Type 1a regulatory subunit]]
[[Category: Type 1a regulatory subunit]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:37:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:15:19 2008''

Revision as of 13:15, 29 July 2008

Image:1rl3.png

Template:STRUCTURE 1rl3

Crystal structure of cAMP-free R1a subunit of PKA

Template:ABSTRACT PUBMED 15274925

About this Structure

1RL3 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B., Wu J, Brown S, Xuong NH, Taylor SS, Structure. 2004 Jun;12(6):1057-65. PMID:15274925

Page seeded by OCA on Tue Jul 29 16:15:19 2008

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