1tl6

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[[Image:1tl6.gif|left|200px]]
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{{STRUCTURE_1tl6| PDB=1tl6 | SCENE= }}
{{STRUCTURE_1tl6| PDB=1tl6 | SCENE= }}
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'''Solution structure of T4 bacteriphage AsiA monomer'''
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===Solution structure of T4 bacteriphage AsiA monomer===
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==Overview==
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Bacteriophage T4 AsiA is a versatile transcription factor capable of inhibiting host gene expression as an 'anti-sigma' factor while simultaneously promoting gene-specific expression of T4 middle genes in conjunction with T4 MotA. To accomplish this task, AsiA engages conserved region 4 of Eschericia coli sigma70, blocking recognition of most host promoters by sequestering the DNA-binding surface at the AsiA/sigma70 interface. The three-dimensional structure of an AsiA/region 4 complex reveals that the C-terminal alpha helix of region 4 is unstructured, while four other helices adopt a completely different conformation relative to the canonical structure of unbound region 4. That AsiA induces, rather than merely stabilizes, this rearrangement can be realized by comparison to the homologous structures of region 4 solved in a variety of contexts, including the structure of Thermotoga maritima sigmaA region 4 described herein. AsiA simultaneously occupies the surface of region 4 that ordinarily contacts core RNA polymerase (RNAP), suggesting that an AsiA-bound sigma70 may also undergo conformational changes in the context of the RNAP holoenzyme.
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(as it appears on PubMed at http://www.pubmed.gov), where 15257291 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15257291}}
==About this Structure==
==About this Structure==
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1TL6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TL6 OCA].
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1TL6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TL6 OCA].
==Reference==
==Reference==
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[[Category: Asia]]
[[Category: Asia]]
[[Category: T4 bacteriophage]]
[[Category: T4 bacteriophage]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:05:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:18:56 2008''

Revision as of 13:19, 29 July 2008

Image:1tl6.png

Template:STRUCTURE 1tl6

Solution structure of T4 bacteriphage AsiA monomer

Template:ABSTRACT PUBMED 15257291

About this Structure

1TL6 is a Single protein structure of sequence from Enterobacteria phage t4. Full experimental information is available from OCA.

Reference

T4 AsiA blocks DNA recognition by remodeling sigma70 region 4., Lambert LJ, Wei Y, Schirf V, Demeler B, Werner MH, EMBO J. 2004 Aug 4;23(15):2952-62. Epub 2004 Jul 15. PMID:15257291

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