1rwl

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[[Image:1rwl.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1rwl| PDB=1rwl | SCENE= }}
{{STRUCTURE_1rwl| PDB=1rwl | SCENE= }}
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'''Extracellular domain of Mycobacterium tuberculosis PknD'''
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===Extracellular domain of Mycobacterium tuberculosis PknD===
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==Overview==
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Diverse pathogenic bacteria produce transmembrane receptor Ser/Thr protein kinases (STPKs), but little is known about the signals mediated by these "eukaryotic-like" proteins. To explore the basis for signaling in the bacterial STPK receptor family, we determined the structure of the sensor domain of Mycobacterium tuberculosis PknD. In two crystal forms, the PknD sensor domain forms a rigid, six-bladed beta-propeller with a flexible tether to the transmembrane domain. The PknD sensor domain is the most symmetric beta-propeller structure described. All residues that vary most among the blade subdomains cluster in the large "cup" motif, analogous to the ligand-binding surface in many beta-propeller proteins. These results suggest that PknD binds a multivalent ligand that signals by changing the quaternary structure of the intracellular kinase domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 15136047 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15136047}}
==About this Structure==
==About this Structure==
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[[Category: Tb structural genomics consortium]]
[[Category: Tb structural genomics consortium]]
[[Category: Tbsgc]]
[[Category: Tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:59:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:24:23 2008''

Revision as of 13:24, 29 July 2008

Image:1rwl.png

Template:STRUCTURE 1rwl

Extracellular domain of Mycobacterium tuberculosis PknD

Template:ABSTRACT PUBMED 15136047

About this Structure

1RWL is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Sensor domain of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknD, forms a highly symmetric beta propeller., Good MC, Greenstein AE, Young TA, Ng HL, Alber T, J Mol Biol. 2004 May 28;339(2):459-69. PMID:15136047

Page seeded by OCA on Tue Jul 29 16:24:23 2008

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