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2tob

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[[Image:2tob.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2tob| PDB=2tob | SCENE= }}
{{STRUCTURE_2tob| PDB=2tob | SCENE= }}
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'''SOLUTION STRUCTURE OF THE TOBRAMYCIN-RNA APTAMER COMPLEX, NMR, 13 STRUCTURES'''
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===SOLUTION STRUCTURE OF THE TOBRAMYCIN-RNA APTAMER COMPLEX, NMR, 13 STRUCTURES===
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==Overview==
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We have solved the solution structure of the aminoglycoside antibiotic tobramycin complexed with a stem-loop RNA aptamer. The 14 base loop of the RNA aptamer 'zippers up' alongside the attached stem through alignment of four mismatches and one Watson-Crick pair on complex formation. The tobramycin inserts into the deep groove centered about the mismatch pairs and is partially encapsulated between its floor and a looped out guanine base that flaps over the bound antibiotic. Several potential intermolecular hydrogen bonds between the charged NH3 groups of tobramycin and acceptor atoms on base pair edges and backbone phosphates anchor the aminoglycoside antibiotic within its sequence/structure specific RNA binding pocket.
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The line below this paragraph, {{ABSTRACT_PUBMED_9731769}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9731769 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9731769}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TOB OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TOB OCA].
==Reference==
==Reference==
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[[Category: Aminoglycoside-rna recognition]]
[[Category: Aminoglycoside-rna recognition]]
[[Category: Tobramycin]]
[[Category: Tobramycin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:25:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:25:01 2008''

Revision as of 13:25, 29 July 2008

Image:2tob.png

Template:STRUCTURE 2tob

SOLUTION STRUCTURE OF THE TOBRAMYCIN-RNA APTAMER COMPLEX, NMR, 13 STRUCTURES

Template:ABSTRACT PUBMED 9731769

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of the tobramycin-RNA aptamer complex., Jiang L, Patel DJ, Nat Struct Biol. 1998 Sep;5(9):769-74. PMID:9731769

Page seeded by OCA on Tue Jul 29 16:25:01 2008

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