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1mse

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[[Image:1mse.gif|left|200px]]
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{{STRUCTURE_1mse| PDB=1mse | SCENE= }}
{{STRUCTURE_1mse| PDB=1mse | SCENE= }}
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'''SOLUTION STRUCTURE OF A SPECIFIC DNA COMPLEX OF THE MYB DNA-BINDING DOMAIN WITH COOPERATIVE RECOGNITION HELICES'''
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===SOLUTION STRUCTURE OF A SPECIFIC DNA COMPLEX OF THE MYB DNA-BINDING DOMAIN WITH COOPERATIVE RECOGNITION HELICES===
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==Overview==
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The DNA-binding region of Myb consists of three imperfect tandem repeats (R1, R2, and R3). We have determined the solution structure of a specific DNA complex of the minimum DNA-binding domain (R2R3) by heteronuclear multidimensional NMR. Both R2 and R3 contain three helices, and the third helix in each is found to be a recognition helix. R2 and R3 are closely packed in the major groove, so that the two recognition helices contact each other directly to bind to the specific base sequence, AACNG cooperatively; this is a significant arrangement of recognition helices. The three key base pairs in this sequence are specifically recognized by Asn-183 (R3), Lys-182 (R3), and Lys-128 (R2). In contrast, R1 has no specific interactions with DNA from our NMR study of the DNA complex of the full DNA-binding domain (R1R2R3).
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The line below this paragraph, {{ABSTRACT_PUBMED_7954830}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7954830 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7954830}}
==About this Structure==
==About this Structure==
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1MSE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSE OCA].
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1MSE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSE OCA].
==Reference==
==Reference==
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[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Protooncogene product]]
[[Category: Protooncogene product]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:40:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:28:25 2008''

Revision as of 13:28, 29 July 2008

Image:1mse.png

Template:STRUCTURE 1mse

SOLUTION STRUCTURE OF A SPECIFIC DNA COMPLEX OF THE MYB DNA-BINDING DOMAIN WITH COOPERATIVE RECOGNITION HELICES

Template:ABSTRACT PUBMED 7954830

About this Structure

1MSE is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices., Ogata K, Morikawa S, Nakamura H, Sekikawa A, Inoue T, Kanai H, Sarai A, Ishii S, Nishimura Y, Cell. 1994 Nov 18;79(4):639-48. PMID:7954830

Page seeded by OCA on Tue Jul 29 16:28:25 2008

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