2hn7

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{{STRUCTURE_2hn7| PDB=2hn7 | SCENE= }}
{{STRUCTURE_2hn7| PDB=2hn7 | SCENE= }}
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'''HLA-A*1101 in complex with HBV peptide homologue'''
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===HLA-A*1101 in complex with HBV peptide homologue===
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==Overview==
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A high-resolution structure of the human MHC-I molecule HLA-A*1101 is presented in which it forms a complex with a sequence homologue of a peptide that occurs naturally in hepatitis B virus DNA polymerase. The sequence of the bound peptide is AIMPARFYPK, while that of the corresponding natural peptide is LIMPARFYPK. The peptide does not make efficient use of the middle E pocket for binding, which leads to a rather superficial and exposed binding mode for the central peptide residues. Despite this, the peptide binds with high affinity (IC50 of 31 nM).
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(as it appears on PubMed at http://www.pubmed.gov), where 17142892 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17142892}}
==Disease==
==Disease==
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Revision as of 13:29, 29 July 2008

Image:2hn7.png

Template:STRUCTURE 2hn7

Contents

HLA-A*1101 in complex with HBV peptide homologue

Template:ABSTRACT PUBMED 17142892

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

2HN7 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue., Blicher T, Kastrup JS, Pedersen LO, Buus S, Gajhede M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt, 12):1179-84. Epub 2006 Nov 4. PMID:17142892

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