1s6c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1s6c.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1s6c.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1s6c| PDB=1s6c | SCENE= }}
{{STRUCTURE_1s6c| PDB=1s6c | SCENE= }}
-
'''Crystal structure of the complex between KChIP1 and Kv4.2 N1-30'''
+
===Crystal structure of the complex between KChIP1 and Kv4.2 N1-30===
-
==Overview==
+
<!--
-
Four Kv channel-interacting proteins (KChIP1 through KChIP4) interact directly with the N-terminal domain of three Shal-type voltage-gated potassium channels (Kv4.1, Kv4.2, and Kv4.3) to modulate cell surface expression and function of Kv4 channels. Here we report a 2.0 Angstrom crystal structure of the core domain of KChIP1 (KChIP1*) in complex with the N-terminal fragment of Kv4.2 (Kv4.2N30). The complex reveals a clam-shaped dimeric assembly. Four EF-hands from each KChIP1 form each shell of the clam. The N-terminal end of Kv4.2 forming an alpha helix (alpha1) and the C-terminal alpha helix (H10) of KChIP1 are enclosed nearly coaxially by these shells. As a result, the H10 of KChIP1 and alpha1 of Kv4.2 mediate interactions between these two molecules, structurally reminiscent of the interactions between calmodulin and its target peptides. Site-specific mutagenesis combined with functional characterization shows that those interactions mediated by alpha1 and H10 are essential to the modulation of Kv4.2 by KChIPs.
+
The line below this paragraph, {{ABSTRACT_PUBMED_14980206}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 14980206 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_14980206}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Zhou, W.]]
[[Category: Zhou, W.]]
[[Category: Ef-hand]]
[[Category: Ef-hand]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:21:27 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:30:35 2008''

Revision as of 13:30, 29 July 2008

Image:1s6c.png

Template:STRUCTURE 1s6c

Crystal structure of the complex between KChIP1 and Kv4.2 N1-30

Template:ABSTRACT PUBMED 14980206

About this Structure

1S6C is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural insights into the functional interaction of KChIP1 with Shal-type K(+) channels., Zhou W, Qian Y, Kunjilwar K, Pfaffinger PJ, Choe S, Neuron. 2004 Feb 19;41(4):573-86. PMID:14980206

Page seeded by OCA on Tue Jul 29 16:30:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1s6c"
Personal tools