1wz7

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{{STRUCTURE_1wz7| PDB=1wz7 | SCENE= }}
{{STRUCTURE_1wz7| PDB=1wz7 | SCENE= }}
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'''Crystal structure of enhancer of rudimentary homologue (ERH)'''
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===Crystal structure of enhancer of rudimentary homologue (ERH)===
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==Overview==
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The enhancer of rudimentary gene, e(r), of Drosophila melanogaster encodes an enhancer of rudimentary (ER) protein with functions implicated in pyrimidine biosynthesis and the cell cycle. The ER homolog (ERH) is highly conserved among vertebrates, invertebrates, and plants. Xenopus laevis ERH was reported to be a transcriptional repressor. Here we report the 2.1 Angstroms crystal structure of murine ERH (Protein Data Bank ID 1WZ7), determined by the multiwavelength anomalous dispersion (MAD) method. The monomeric structure of ERH comprises a single domain consisting of three alpha-helices and four beta-strands, which is a novel fold. In the crystal structure, ERH assumes a dimeric structure, through interactions between the beta-sheet regions. The formation of an ERH dimer is consistent with the results of analytical ultracentrifugation. The residues at the core region and at the dimer interface are highly conserved, suggesting the conservation of the dimer formation as well as the monomer fold. The long flexible loop (44 approximately 53) is also significantly conserved, suggesting that this loop region may be important for the functions of ERH. In addition, the putative phosphorylation sites are located at the start of the beta2-strand (Thr18) and at the start of the alpha1-helix (Ser24), implying that the phosphorylation might cause some structural changes.
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(as it appears on PubMed at http://www.pubmed.gov), where 15937287 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15937287}}
==About this Structure==
==About this Structure==
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[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:33:09 2008''

Revision as of 13:33, 29 July 2008

Image:1wz7.png

Template:STRUCTURE 1wz7

Crystal structure of enhancer of rudimentary homologue (ERH)

Template:ABSTRACT PUBMED 15937287

About this Structure

1WZ7 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of an enhancer of rudimentary homolog (ERH) at 2.1 Angstroms resolution., Arai R, Kukimoto-Niino M, Uda-Tochio H, Morita S, Uchikubo-Kamo T, Akasaka R, Etou Y, Hayashizaki Y, Kigawa T, Terada T, Shirouzu M, Yokoyama S, Protein Sci. 2005 Jul;14(7):1888-93. Epub 2005 Jun 3. PMID:15937287

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