2p6w

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{{STRUCTURE_2p6w| PDB=2p6w | SCENE= }}
{{STRUCTURE_2p6w| PDB=2p6w | SCENE= }}
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'''Crystal structure of a glycosyltransferase involved in the glycosylation of the major capsid of PBCV-1'''
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===Crystal structure of a glycosyltransferase involved in the glycosylation of the major capsid of PBCV-1===
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==Overview==
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Paramecium bursaria chlorella virus-1 encodes at least five putative glycosyltransferases that are probably involved in the synthesis of the glycan components of the viral major capsid protein. The 1.6 A crystal structure of one of these glycosyltransferases (A64R) has a mixed alpha/beta fold containing a central, six-stranded beta sheet flanked by alpha helices. Crystal structures of A64R, complexed with UDP, CMP, or GDP, established that only UDP bound to A64R in the presence of Mn(2+), consistent with its high structural similarity to glycosyltransferases which utilize UDP as the sugar carrier. The structure of the complex of A64R, UDP-glucose, and Mn(2+) showed that the largest conformational change occurred when hydrogen bonds were formed with the ligands. Unlike UDP-glucose, UDP-galactose and UDP-GlcNAc did not bind to A64R, suggesting a selective binding of UDP-glucose. Thus, UDP-glucose is most likely the sugar donor for A64R, consistent with glucose occurring in the virus major capsid protein glycans.
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The line below this paragraph, {{ABSTRACT_PUBMED_17850743}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17850743 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17850743}}
==About this Structure==
==About this Structure==
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[[Category: Glycosyltransferase]]
[[Category: Glycosyltransferase]]
[[Category: Pbcv]]
[[Category: Pbcv]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:30:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:36:20 2008''

Revision as of 13:36, 29 July 2008

Image:2p6w.png

Template:STRUCTURE 2p6w

Crystal structure of a glycosyltransferase involved in the glycosylation of the major capsid of PBCV-1

Template:ABSTRACT PUBMED 17850743

About this Structure

2P6W is a Single protein structure of sequence from Paramecium bursaria chlorella virus 1. Full crystallographic information is available from OCA.

Reference

Structure and function of a chlorella virus-encoded glycosyltransferase., Zhang Y, Xiang Y, Van Etten JL, Rossmann MG, Structure. 2007 Sep;15(9):1031-9. PMID:17850743

Page seeded by OCA on Tue Jul 29 16:36:20 2008

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