1pve

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{{STRUCTURE_1pve| PDB=1pve | SCENE= }}
{{STRUCTURE_1pve| PDB=1pve | SCENE= }}
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'''Solution structure of XPC binding domain of hHR23B'''
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===Solution structure of XPC binding domain of hHR23B===
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==Overview==
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Human cells contain two homologs of the yeast RAD23 protein, hHR23A and hHR23B, which participate in the DNA repair process. hHR23B houses a domain (residues 277-332, called XPCB) that binds specifically and directly to the xeroderma pigmentosum group C protein (XPC) to initiate nucleotide excision repair (NER). This domain shares sequence homology with a heat shock chaperonin-binding motif that is also found in the stress-inducible yeast phosphoprotein STI1. We determined the solution structure of a protein fragment containing amino acids 275-342 of hHR23B (termed XPCB-hHR23B) and compared it with the previously reported solution structures of the corresponding domain of hHR23A. The periodic positioning of proline residues in XPCB-hHR23B produced kinked alpha helices and assisted in the formation of a compact domain. Although the overall structure of the XPCB domain was similar in both XPCB-hHR23B and XPCB-hHR23A, the N-terminal part (residues 275-283) of XPCB-hHR23B was more flexible than the corresponding part of hHR23A. We tried to infer the characteristics of this flexibility through (15)N-relaxation studies. The hydrophobic surface of XPCB-hHR23B, which results from the diverse distribution of N-terminal region, might give rise to the functional pleiotropy observed in vivo for hHR23B, but not for hHR23A.
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{{ABSTRACT_PUBMED_15885096}}
==About this Structure==
==About this Structure==
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1PVE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PVE OCA].
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1PVE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PVE OCA].
==Reference==
==Reference==
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[[Category: Nucleotide excision repair]]
[[Category: Nucleotide excision repair]]
[[Category: Xpc binding domain]]
[[Category: Xpc binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:31:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:38:48 2008''

Revision as of 13:38, 29 July 2008

Image:1pve.png

Template:STRUCTURE 1pve

Solution structure of XPC binding domain of hHR23B

Template:ABSTRACT PUBMED 15885096

About this Structure

1PVE is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure and backbone dynamics of the XPC-binding domain of the human DNA repair protein hHR23B., Kim B, Ryu KS, Kim HJ, Cho SJ, Choi BS, FEBS J. 2005 May;272(10):2467-76. PMID:15885096

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