1qz8
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(New page: 200px<br /><applet load="1qz8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qz8, resolution 2.70Å" /> '''Crystal structure of...)
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Revision as of 23:01, 20 November 2007
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Crystal structure of SARS coronavirus NSP9
Overview
The recently identified etiological agent of the severe acute respiratory, syndrome (SARS) belongs to Coronaviridae (CoV), a family of viruses, replicating by a poorly understood mechanism. Here, we report the crystal, structure at 2.7-A resolution of nsp9, a hitherto uncharacterized subunit, of the SARS-CoV replicative polyproteins. We show that SARS-CoV nsp9 is a, single-stranded RNA-binding protein displaying a previously unreported, oligosaccharide/oligonucleotide fold-like fold. The presence of this type, of protein has not been detected in the replicative complexes of RNA, viruses, and its presence may reflect the unique and complex CoV viral, replication/transcription machinery.
About this Structure
1QZ8 is a Single protein structure of sequence from Human sars coronavirus with SO4 as ligand. Full crystallographic information is available from OCA.
Reference
The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world., Egloff MP, Ferron F, Campanacci V, Longhi S, Rancurel C, Dutartre H, Snijder EJ, Gorbalenya AE, Cambillau C, Canard B, Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3792-6. Epub 2004 Mar 8. PMID:15007178
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