1r09
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(New page: 200px<br /><applet load="1r09" size="450" color="white" frame="true" align="right" spinBox="true" caption="1r09, resolution 2.9Å" /> '''HUMAN RHINOVIRUS 14 C...)
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Revision as of 23:02, 20 November 2007
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HUMAN RHINOVIRUS 14 COMPLEXED WITH ANTIVIRAL COMPOUND R 61837
Overview
The binding of the antirhinoviral agent R 61837 to human rhinovirus 14 has, been examined by X-ray crystallographic methods. The compound R 61837, binds in the same pocket (underneath the canyon floor) as the "WIN", antirhinoviral agents. It does not penetrate as far into the pocket but, causes similar conformational changes in the virus capsid. The movement of, residues 1217 to 1221 of viral protein 1 (in the "FMDV loop") is more, pronounced for R 61837 than for WIN compounds. Although both R 61837 and, WIN antiviral agents partially fill the same hydrophobic pocket, atomic, binding interactions differ, showing that considerable diversity in the, nature of antiviral agents is possible.
About this Structure
1R09 is a Protein complex structure of sequences from Human rhinovirus 10 with JEN and DMS as ligands. Full crystallographic information is available from OCA.
Reference
Human rhinovirus 14 complexed with antiviral compound R 61837., Chapman MS, Minor I, Rossmann MG, Diana GD, Andries K, J Mol Biol. 1991 Feb 5;217(3):455-63. PMID:1847215
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