Immunodeficiency virus protease
From Proteopedia
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Saquinavir was the the first FDA approved protease inhibitor. | Saquinavir was the the first FDA approved protease inhibitor. | ||
| - | Looking at the structure of HIV-1 protease, we see that the protein is composed of <scene name='HIV-1_protease/2nmz_symmetric/2'>two symmetrically related subunits</scene>. Each subunit consists of the same small chain of only 99 amino acids. The subunits come together in such as way as to <scene name='HIV-1_protease/2nmz_tunnel/1'>form a tunnel where they meet</scene>. The protein to-be-cleaved sits in this tunnel. In the middle of the tunnel is the active site of the protease: an Asp-Thr-Gly (25, 26, and 27) catalytic triad withthe two Asps acting as the catalytic residues. | + | Looking at the structure of HIV-1 protease, we see that the protein is composed of <scene name='HIV-1_protease/2nmz_symmetric/2'>two symmetrically related subunits</scene>, shown here in [[cartoon backbone representation]] to highlight [[secondary structure]]. Each subunit consists of the same small chain of only 99 amino acids. The subunits come together in such as way as to <scene name='HIV-1_protease/2nmz_tunnel/1'>form a tunnel where they meet</scene>, shown here in [[spacefilling representation]] to showcase the physical surface of the protein. The protein to-be-cleaved sits in this tunnel. In the middle of the tunnel is the active site of the protease: an Asp-Thr-Gly (25, 26, and 27) catalytic triad withthe two Asps acting as the catalytic residues. |
<scene name='HIV-1_protease/Hiv1_protease_morph/1'>The flaps move</scene> (large scene, takes a while to load) to allow proteins to enter the tunnel. | <scene name='HIV-1_protease/Hiv1_protease_morph/1'>The flaps move</scene> (large scene, takes a while to load) to allow proteins to enter the tunnel. | ||
Revision as of 18:07, 16 August 2008
Template:STRUCTURE 1hhp HIV is a notoriously lethal virus that is known to cause AIDS. There currently is no cure or vaccine. But, scientists have discovered treatments that can slow progression of the HIV virus, thanks in large part to our understanding of the structure of HIV-1 protease, seen here on the right in complex with a potent drug used for slowing the progression of HIV, .
HIV-1 protease is a protein made by the HIV virus that is crucial to the virus's infectious capacity. The virus makes certain proteins that need to be cleaved, or cut, in order to transform into mature, fully-functional proteins that can allow the virus to infect new cells. HIV-1 protease is responsible for cleaving these nascent proteins into their mature form.
Saquinavir was the the first FDA approved protease inhibitor.
Looking at the structure of HIV-1 protease, we see that the protein is composed of , shown here in cartoon backbone representation to highlight secondary structure. Each subunit consists of the same small chain of only 99 amino acids. The subunits come together in such as way as to , shown here in spacefilling representation to showcase the physical surface of the protein. The protein to-be-cleaved sits in this tunnel. In the middle of the tunnel is the active site of the protease: an Asp-Thr-Gly (25, 26, and 27) catalytic triad withthe two Asps acting as the catalytic residues.
(large scene, takes a while to load) to allow proteins to enter the tunnel.
PAGE IN PROGRESS Eran Hodis 19:10, 15 August 2008 (IDT)
This page is not a fully developed page, but was created as an example for the press release of the Proteopedia article in the open-access journal Genome Biology. Please expand this page with additional information and references.
Proteopedia Page Contributors and Editors (what is this?)
Joel L. Sussman, Michal Harel, Eran Hodis, Mark Hoelzer, David Canner, Eric Martz, Ann Taylor, Wayne Decatur, Alexander Berchansky, Jaime Prilusky, Karsten Theis
