2oar
From Proteopedia
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{{STRUCTURE_2oar| PDB=2oar | SCENE= }} | {{STRUCTURE_2oar| PDB=2oar | SCENE= }} | ||
| - | + | ===Mechanosensitive Channel of Large Conductance (MscL)=== | |
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| - | + | The line below this paragraph, {{ABSTRACT_PUBMED_9856938}}, adds the Publication Abstract to the page | |
| + | (as it appears on PubMed at http://www.pubmed.gov), where 9856938 is the PubMed ID number. | ||
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==About this Structure== | ==About this Structure== | ||
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[[Category: Strop, P.]] | [[Category: Strop, P.]] | ||
[[Category: Stretch activated ion channel mechanosensitive]] | [[Category: Stretch activated ion channel mechanosensitive]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
| + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 20 12:12:19 2008'' | ||
Revision as of 09:12, 20 August 2008
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| 2oar, resolution 3.50Å () | |||||||
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| Ligands: | |||||||
| Gene: | mscL (MYCTA) | ||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Mechanosensitive Channel of Large Conductance (MscL)
Mechanosensitive ion channels play a critical role in transducing physical stresses at the cell membrane into an electrochemical response. The MscL family of large-conductance mechanosensitive channels is widely distributed among prokaryotes and may participate in the regulation of osmotic pressure changes within the cell. In an effort to better understand the structural basis for the function of these channels, the structure of the MscL homolog from Mycobacterium tuberculosis was determined by x-ray crystallography to 3.5 angstroms resolution. This channel is organized as a homopentamer, with each subunit containing two transmembrane alpha helices and a third cytoplasmic alpha helix. From the extracellular side, a water-filled opening approximately 18 angstroms in diameter leads into a pore lined with hydrophilic residues which narrows at the cytoplasmic side to an occluded hydrophobic apex that may act as the channel gate. This structure may serve as a model for other mechanosensitive channels, as well as the broader class of pentameric ligand-gated ion channels exemplified by the nicotinic acetylcholine receptor.
Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel., Chang G, Spencer RH, Lee AT, Barclay MT, Rees DC, Science. 1998 Dec 18;282(5397):2220-6. PMID:9856938
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2OAR is a Single protein structure of sequence from Mycobacterium tuberculosis. This structure supersedes the now removed PDB entry 1msl. Full crystallographic information is available from OCA.
Reference
Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel., Chang G, Spencer RH, Lee AT, Barclay MT, Rees DC, Science. 1998 Dec 18;282(5397):2220-6. PMID:9856938
Page seeded by OCA on Wed Aug 20 12:12:19 2008
