3cf2

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{{STRUCTURE_3cf2| PDB=3cf2 | SCENE= }}
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'''Structure of P97/vcp in complex with ADP/AMP-PNP'''
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===Structure of P97/vcp in complex with ADP/AMP-PNP===
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==Overview==
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The ATPase p97/VCP affects multiple events within the cell. These events include the alteration of both nuclear and mitotic Golgi membranes, the dislocation of ubiquitylated proteins from the endoplasmic reticulum and regulation of the NF-kappa b pathway. Here we present the crystal structure of full-length Mus musculus p97/VCP in complex with a mixture of ADP and ADP-AlF(x) at a resolution of 4.7 A. This is the first complete hexameric structure of a protein containing tandem AAA (ATPases associated with a variety of cellular activities) domains. Comparison of the crystal structure and cryo-electron microscopy (EM) reconstructions reveals large conformational changes in the helical subdomains during the hydrolysis cycle. Structural and functional data imply a communication mechanism between the AAA domains. A Zn(2+) occludes the central pore of the hexamer, suggesting that substrate does not thread through the pore of the molecule.
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{{ABSTRACT_PUBMED_12949490}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains., DeLaBarre B, Brunger AT, Nat Struct Biol. 2003 Oct;10(10):856-63. Epub 2003 Aug 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12949490 12949490]
Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains., DeLaBarre B, Brunger AT, Nat Struct Biol. 2003 Oct;10(10):856-63. Epub 2003 Aug 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12949490 12949490]
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Nucleotide dependent motion and mechanism of action of p97/VCP., DeLaBarre B, Brunger AT, J Mol Biol. 2005 Mar 25;347(2):437-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15740751 15740751]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Erad]]
[[Category: Erad]]
[[Category: Transport protein]]
[[Category: Transport protein]]
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Revision as of 09:13, 20 August 2008

Image:3cf2.png

Template:STRUCTURE 3cf2

Structure of P97/vcp in complex with ADP/AMP-PNP

Template:ABSTRACT PUBMED 12949490

About this Structure

3CF2 is a Single protein structure of sequence from Mus musculus. This structure supersedes the now removed PDB entry 1ypw. Full crystallographic information is available from OCA.

Reference

Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains., DeLaBarre B, Brunger AT, Nat Struct Biol. 2003 Oct;10(10):856-63. Epub 2003 Aug 31. PMID:12949490

Nucleotide dependent motion and mechanism of action of p97/VCP., DeLaBarre B, Brunger AT, J Mol Biol. 2005 Mar 25;347(2):437-52. PMID:15740751

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