2jv3

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{{STRUCTURE_2jv3| PDB=2jv3 | SCENE= }}
{{STRUCTURE_2jv3| PDB=2jv3 | SCENE= }}
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'''Ets-1 PNT domain (29-138) NMR structure ensemble'''
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===Ets-1 PNT domain (29-138) NMR structure ensemble===
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==Overview==
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The Pointed (PNT) domain and an adjacent mitogen-activated protein (MAP) kinase phosphorylation site are defined by sequence conservation among a subset of ets transcription factors and are implicated in two regulatory strategies, protein interactions and posttranslational modifications, respectively. By using NMR, we have determined the structure of a 110-residue fragment of murine Ets-1 that includes the PNT domain and MAP kinase site. The Ets-1 PNT domain forms a monomeric five-helix bundle. The architecture is distinct from that of any known DNA- or protein-binding module, including the helix-loop-helix fold proposed for the PNT domain of the ets protein TEL. The MAP kinase site is in a highly flexible region of both the unphosphorylated and phosphorylated forms of the Ets-1 fragment. Phosphorylation alters neither the structure nor monomeric state of the PNT domain. These results suggest that the Ets-1 PNT domain functions in heterotypic protein interactions and support the possibility that target recognition is coupled to structuring of the MAP kinase site.
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{{ABSTRACT_PUBMED_9770451}}
==About this Structure==
==About this Structure==
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2JV3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bqv 1bqv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JV3 OCA].
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2JV3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bqv 1bqv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JV3 OCA].
==Reference==
==Reference==
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[[Category: Nucleus]]
[[Category: Nucleus]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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Revision as of 09:16, 20 August 2008

Image:2jv3.png

Template:STRUCTURE 2jv3

Ets-1 PNT domain (29-138) NMR structure ensemble

Template:ABSTRACT PUBMED 9770451

About this Structure

2JV3 is a Single protein structure of sequence from Mus musculus. This structure supersedes the now removed PDB entry 1bqv. Full experimental information is available from OCA.

Reference

Structure of the Ets-1 pointed domain and mitogen-activated protein kinase phosphorylation site., Slupsky CM, Gentile LN, Donaldson LW, Mackereth CD, Seidel JJ, Graves BJ, McIntosh LP, Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12129-34. PMID:9770451

Page seeded by OCA on Wed Aug 20 12:16:19 2008

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