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2h0n

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'''Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC'''
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===Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC===
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==Overview==
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CeNA oligonucleotides consist of a phosphorylated backbone where the deoxyribose sugars are replaced by cyclohexene moieties. The X-ray structure determination and analysis of a fully modified octamer sequence GTGTACAC, which is the first crystal structure of a carbocyclic-based nucleic acid, is presented. This particular sequence was built with left-handed building blocks and crystallizes as a left-handed double helix. The helix can be characterized as belonging to the (mirrored) A-type family. Crystallographic data were processed up to 1.53 A, and the octamer sequence crystallizes in the space group R32. The sugar puckering is found to adopt the 3H2 half-chair conformation which mimics the C3'-endo conformation of the ribose sugar. The double helices stack on top of each other to form continuous helices, and static disorder is observed due to this end-to-end stacking.
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{{ABSTRACT_PUBMED_18198873}}
==About this Structure==
==About this Structure==
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[[Category: Double helix]]
[[Category: Double helix]]
[[Category: Left-handed]]
[[Category: Left-handed]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:43:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 10 10:32:51 2008''

Revision as of 07:32, 10 September 2008

Image:2h0n.png

Template:STRUCTURE 2h0n

Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC

Template:ABSTRACT PUBMED 18198873

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC., Robeyns K, Herdewijn P, Van Meervelt L, J Am Chem Soc. 2008 Feb 13;130(6):1979-84. Epub 2008 Jan 17. PMID:18198873

Page seeded by OCA on Wed Sep 10 10:32:51 2008

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