This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1rlg
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="1rlg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rlg, resolution 2.7Å" /> '''Molecular basis of Bo...)
Next diff →
Revision as of 23:34, 20 November 2007
|
Molecular basis of Box C/D RNA-protein interaction: co-crystal structure of the Archaeal sRNP intiation complex
Overview
We have determined and refined a crystal structure of the initial assembly, complex of archaeal box C/D sRNPs comprising the Archaeoglobus fulgidus, (AF) L7Ae protein and a box C/D RNA. The box C/D RNA forms a classical, kink-turn (K-turn) structure and the resulting protein-RNA complex serves, as a distinct platform for recruitment of the fibrillarin-Nop5p complex., The cocrystal structure confirms previously proposed secondary structure, of the box C/D RNA that includes a protruded U, a UU mismatch, and two, sheared tandem GA base pairs. Detailed structural comparisons of the AF, L7Ae-box C/D RNA complex with previously determined crystal structures of, L7Ae homologs in complex with functionally distinct K-turn RNAs revealed a, set of remarkably conserved principles in protein-RNA interactions. These, analyses provide a structural basis for interpreting the functional roles, of the box C/D sequences in directing specific assembly of box C/D sRNPs.
About this Structure
1RLG is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.
Reference
Molecular basis of box C/D RNA-protein interactions; cocrystal structure of archaeal L7Ae and a box C/D RNA., Moore T, Zhang Y, Fenley MO, Li H, Structure. 2004 May;12(5):807-18. PMID:15130473
Page seeded by OCA on Wed Nov 21 01:41:16 2007
