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1hpj
From Proteopedia
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(New page: 200px<br /> <applet load="1hpj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hpj" /> '''SOLUTION NMR STRUCTURE OF THE HUMAN PLASMIN...)
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Revision as of 18:54, 29 October 2007
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SOLUTION NMR STRUCTURE OF THE HUMAN PLASMINOGEN KRINGLE 1 DOMAIN COMPLEXED WITH 6-AMINOHEXANOIC ACID AT PH 5.3, 310K, DERIVED FROM RANDOMLY GENERATED STRUCTURES USING SIMULATED ANNEALING, 12 STRUCTURES
Overview
The solution structure of the human plasminogen kringle 1 domain complexed, to the antifibrinolytic drug 6-aminohexanoic acid (epsilon Ahx) was, obtained on the basis of 1H-NMR spectroscopic data and dynamical simulated, annealing calculations. Two sets of structures were derived starting from, (a) random coil conformations and (b) the (mutated) crystallographic, structure of the homologous prothrombin kringle 1. The two sets display, essentially the same backbone folding (pairwise root-mean-square, deviation, 0.15 nm) indicating that, regardless of the initial structure, the data is sufficient to locate a conformation corresponding to an, essentially unique energy minimum. The conformations of residues connected, to prolines were localized to energetically preferred regions of the, ... [(full description)]
About this Structure
1HPJ is a [Single protein] structure of sequence from [Homo sapiens]. Active as [[1]], with EC number [3.4.21.7]. Full crystallographic information is available from [OCA].
Reference
Solution structure of the epsilon-aminohexanoic acid complex of human plasminogen kringle 1., Rejante MR, Llinas M, Eur J Biochem. 1994 May 1;221(3):939-49. PMID:8181476
Page seeded by OCA on Mon Oct 29 20:59:07 2007
