1s0u

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(New page: 200px<br /><applet load="1s0u" size="450" color="white" frame="true" align="right" spinBox="true" caption="1s0u, resolution 2.4&Aring;" /> '''eIF2gamma apo'''<br /...)
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Revision as of 23:54, 20 November 2007

Image:1s0u.jpg

1s0u, resolution 2.4Å

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eIF2gamma apo

Overview

The x-ray structure of the gamma-subunit of the heterotrimeric translation, initiation factor eIF2 has been determined to 2.4-A resolution. eIF2 is a, GTPase that delivers the initiator Met-tRNA to the P site on the small, ribosomal subunit during a rate-limiting initiation step in translation., The structure of eIF2gamma closely resembles that of EF1A.GTP, consisting, of an N-terminal G domain followed by two beta-barrels arranged in a, closed configuration with domain II packed against the G domain in the, vicinity of the Switch regions. The G domain of eIF2gamma has an unusual, zinc ribbon motif, not previously found in other GTPases. Structure-based, site-directed mutagenesis was used to identify two adjacent features on, the surface of eIF2gamma that bind the alpha-subunit and Met-tRNA(i)(Met), respectively. These structural, biochemical, and genetic results provide, new insights into eIF2 ternary complex assembly.

About this Structure

1S0U is a Single protein structure of sequence from Methanocaldococcus jannaschii with ZN as ligand. Full crystallographic information is available from OCA.

Reference

X-ray structure of translation initiation factor eIF2gamma: implications for tRNA and eIF2alpha binding., Roll-Mecak A, Alone P, Cao C, Dever TE, Burley SK, J Biol Chem. 2004 Mar 12;279(11):10634-42. Epub 2003 Dec 19. PMID:14688270

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