1s17

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Revision as of 23:54, 20 November 2007

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spinqualitylabelsall models 1s17, resolution 1.95Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Identification of Novel Potent Bicyclic Peptide Deformylase Inhibitors

Overview

Screening of our compound collection using Staphylococcus aureus, Ni-Peptide deformylase (PDF) afforded a very potent PDF inhibitor with an, IC(50) in the low nanomolar range but with poor antibacterial activity, (MIC). Three-dimensional structural information obtained from Pseudomonas, aeruginosa Ni-PDF complexed with the inhibitor suggested the synthesis of, a variety of analogues that would maintain high binding affinity while, attempting to improve antibacterial activity. Many of the compounds, synthesized proved to be excellent PDF-Ni inhibitors and some showed, increased antibacterial activity in selected strains.

About this Structure

1S17 is a Single protein structure of sequence from Pseudomonas aeruginosa with NI, GNR and GOL as ligands. Active as Peptide deformylase, with EC number 3.5.1.88 Full crystallographic information is available from OCA.

Reference

Identification of novel potent bicyclic peptide deformylase inhibitors., Molteni V, He X, Nabakka J, Yang K, Kreusch A, Gordon P, Bursulaya B, Warner I, Shin T, Biorac T, Ryder NS, Goldberg R, Doughty J, He Y, Bioorg Med Chem Lett. 2004 Mar 22;14(6):1477-81. PMID:15006385

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