1s1j
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(New page: 200px<br /><applet load="1s1j" size="450" color="white" frame="true" align="right" spinBox="true" caption="1s1j, resolution 2.18Å" /> '''Crystal Structure of...)
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Revision as of 23:55, 20 November 2007
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Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1
Overview
The binding of FtsZ to ZipA is a potential target for antibacterial, therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key, region of ZipA involved in FtsZ binding. The X-ray crystal structure of, one of these molecules complexed with ZipA was solved. The structure, revealed an unexpected binding mode, facilitated by desolvation of a, loosely bound surface water.
About this Structure
1S1J is a Single protein structure of sequence from Escherichia coli with IQZ as ligand. Full crystallographic information is available from OCA.
Reference
Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction., Jennings LD, Foreman KW, Rush TS 3rd, Tsao DH, Mosyak L, Li Y, Sukhdeo MN, Ding W, Dushin EG, Kenny CH, Moghazeh SL, Petersen PJ, Ruzin AV, Tuckman M, Sutherland AG, Bioorg Med Chem Lett. 2004 Mar 22;14(6):1427-31. PMID:15006376
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