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1sbb
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(New page: 200px<br /><applet load="1sbb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sbb, resolution 2.4Å" /> '''T-CELL RECEPTOR BETA ...)
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Revision as of 00:07, 21 November 2007
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T-CELL RECEPTOR BETA CHAIN COMPLEXED WITH SUPERANTIGEN SEB
Overview
Superantigens (SAGs) are a class of immunostimulatory proteins of, bacterial or viral origin that activate T cells by binding to the V beta, domain of the T cell antigen receptor (TCR). The three-dimensional, structure of the complex between a TCR beta chain (mouse V beta8.2) and, the SAG staphylococcal enterotoxin B (SEB) at 2.4 A resolution reveals why, SEB recognizes only certain V beta families, as well as why only certain, SAGs bind mouse V beta8.2. Models of the TCR-SEB-peptide/MHC class II, complex indicate that V alpha interacts with the MHC beta chain in the, TCR-SAG-MHC complex. The extent of the interaction is variable and is, largely determined by the geometry of V alpha/V beta domain association., This variability can account for the preferential expression of certain V, alpha regions among T cells reactive with SEB.
About this Structure
1SBB is a Protein complex structure of sequences from Mus musculus and Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the complex between a T cell receptor beta chain and the superantigen staphylococcal enterotoxin B., Li H, Llera A, Tsuchiya D, Leder L, Ysern X, Schlievert PM, Karjalainen K, Mariuzza RA, Immunity. 1998 Dec;9(6):807-16. PMID:9881971
Page seeded by OCA on Wed Nov 21 02:14:37 2007
