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1scm
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(New page: 200px<br /><applet load="1scm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1scm, resolution 2.8Å" /> '''STRUCTURE OF THE REGU...)
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Revision as of 00:09, 21 November 2007
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STRUCTURE OF THE REGULATORY DOMAIN OF SCALLOP MYOSIN AT 2.8 ANGSTROMS RESOLUTION
Overview
The regulatory domain of scallop myosin is a three-chain protein complex, that switches on this motor in response to Ca2+ binding. This domain has, been crystallized and the structure solved to 2.8 A resolution. Side-chain, interactions link the two light chains in tandem to adjacent segments of, the heavy chain bearing the IQ-sequence motif. The Ca(2+)-binding site is, a novel EF-hand motif on the essential light chain and is stabilized by, linkages involving the heavy chain and both light chains, accounting for, the requirement of all three chains for Ca2+ binding and regulation in the, intact myosin molecule.
About this Structure
1SCM is a Protein complex structure of sequences from Argopecten irradians with CA as ligand. Full crystallographic information is available from OCA.
Reference
Structure of the regulatory domain of scallop myosin at 2.8 A resolution., Xie X, Harrison DH, Schlichting I, Sweet RM, Kalabokis VN, Szent-Gyorgyi AG, Cohen C, Nature. 1994 Mar 24;368(6469):306-12. PMID:8127365
Page seeded by OCA on Wed Nov 21 02:16:35 2007
