2h9u

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{{STRUCTURE_2h9u| PDB=2h9u | SCENE= }}
{{STRUCTURE_2h9u| PDB=2h9u | SCENE= }}
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'''Crystal structure of the archaea specific DNA binding protein'''
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===Crystal structure of the archaea specific DNA binding protein===
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==Overview==
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Eukaryotic DNA is packaged into nucleosomes that regulate the accessibility of the genome to replication, transcription and repair factors. Chromatin accessibility is controlled by histone modifications including acetylation and methylation. Archaea possess eukary otic-like machineries for DNA replication, transcription and information processing. The conserved archaeal DNA binding protein Alba (formerly Sso10b) interacts with the silencing protein Sir2, which regulates Alba's DNA binding affinity by deacetylation of a lysine residue. We present the crystal structure of Alba from Sulfolobus solfataricus at 2.6 A resolution (PDB code 1h0x). The fold is reminiscent of the N-terminal DNA binding domain of DNase I and the C-terminal domain of initiation factor IF3. The Alba dimer has two extended beta-hairpins flanking a central body containing the acetylated lysine, Lys16, suggesting three main points of contact with the DNA. Fluorescence, calorimetry and electrophoresis data suggest a final binding stoichiometry of approximately 5 bp DNA per Alba dimer. We present a model for the Alba-DNA interaction consistent with the available structural, biophysical and electron microscopy data.
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(as it appears on PubMed at http://www.pubmed.gov), where 12198167 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12198167}}
==About this Structure==
==About this Structure==
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[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:02:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Sep 28 23:53:48 2008''

Revision as of 20:54, 28 September 2008

Image:2h9u.png

Template:STRUCTURE 2h9u

Crystal structure of the archaea specific DNA binding protein

Template:ABSTRACT PUBMED 12198167

About this Structure

2H9U is a Single protein structure of sequence from Aeropyrum pernix. Full crystallographic information is available from OCA.

Reference

Structure of Alba: an archaeal chromatin protein modulated by acetylation., Wardleworth BN, Russell RJ, Bell SD, Taylor GL, White MF, EMBO J. 2002 Sep 2;21(17):4654-62. PMID:12198167

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