1sdb
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(New page: 200px<br /><applet load="1sdb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sdb, resolution 1.65Å" /> '''PORCINE DESB1-2 DESP...)
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Revision as of 00:10, 21 November 2007
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PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN
Overview
Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures, that it circulates and exerts its physiological functions in vivo as a, monomer. The crystal structure of monomeric porcine desB1-B2, despentapeptide (B26-B30) insulin (DesB1-2 DPI) with M(r) = 4934 Da has, been determined at 1.65 A resolution using the molecular replacement, method. A structural comparison between DesB1-2 DPI and 2Zn insulin, reveals that the conformation of DesB1-2 DPI is more similar to molecule I, than molecule II of 2Zn insulin. The remarkable conformational difference, between B25-Phe in DesB1-2 DPI and B25-Phe in despentapeptide (B26-B30), insulin (DPI) indicates that the residue B25-Phe possesses great, flexibility and mobility.
About this Structure
1SDB is a Protein complex structure of sequences from Sus scrofa. Full crystallographic information is available from OCA.
Reference
Structure of monomeric porcine DesB1-B2 despentapeptide (B26-B30) insulin at 1.65 A resolution., Diao JS, Wan ZL, Chang WR, Liang DC, Acta Crystallogr D Biol Crystallogr. 1997 Sep 1;53(Pt 5):507-12. PMID:15299880
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