1sfk

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Revision as of 00:13, 21 November 2007

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spinqualitylabelsall models 1sfk, resolution 3.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Core (C) protein from West Nile Virus, subtype Kunjin

Overview

We have determined the crystal structure of the core (C) protein from the, Kunjin subtype of West Nile virus (WNV), closely related to the NY99, strain of WNV, currently a major health threat in the U.S. WNV is a member, of the Flaviviridae family of enveloped RNA viruses that contains many, important human pathogens. The C protein is associated with the RNA genome, and forms the internal core which is surrounded by the envelope in the, virion. The C protein structure contains four alpha helices and forms, dimers that are organized into tetramers. The tetramers form extended, filamentous ribbons resembling the stacked alpha helices seen in HEAT, protein structures.

About this Structure

1SFK is a Single protein structure of sequence from Kunjin virus with CA, CL, PO4 and PG4 as ligands. Full crystallographic information is available from OCA.

Reference

West Nile virus core protein; tetramer structure and ribbon formation., Dokland T, Walsh M, Mackenzie JM, Khromykh AA, Ee KH, Wang S, Structure. 2004 Jul;12(7):1157-63. PMID:15242592

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