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1sjm

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(New page: 200px<br /><applet load="1sjm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sjm, resolution 1.40&Aring;" /> '''Nitrite bound copper...)
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Revision as of 00:18, 21 November 2007

Image:1sjm.gif

1sjm, resolution 1.40Å

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Nitrite bound copper containing nitrite reductase

Overview

A copper-nitrosyl intermediate forms during the catalytic cycle of nitrite, reductase, the enzyme that mediates the committed step in bacterial, denitrification. The crystal structure of a type 2 copper-nitrosyl complex, of nitrite reductase reveals an unprecedented side-on binding mode in, which the nitrogen and oxygen atoms are nearly equidistant from the copper, cofactor. Comparison of this structure with a refined nitrite-bound, crystal structure explains how coordination can change between, copper-oxygen and copper-nitrogen during catalysis. The side-on, copper-nitrosyl in nitrite reductase expands the possibilities for nitric, oxide interactions in copper proteins such as superoxide dismutase and, prions.

About this Structure

1SJM is a Single protein structure of sequence from Alcaligenes faecalis with CU, NO2, ACT and TRS as ligands. Active as Nitrite reductase (NO-forming), with EC number 1.7.2.1 Full crystallographic information is available from OCA.

Reference

Side-on copper-nitrosyl coordination by nitrite reductase., Tocheva EI, Rosell FI, Mauk AG, Murphy ME, Science. 2004 May 7;304(5672):867-70. PMID:15131305

Page seeded by OCA on Wed Nov 21 02:25:31 2007

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