1skn
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(New page: 200px<br /><applet load="1skn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1skn, resolution 2.500Å" /> '''THE BINDING DOMAIN ...)
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Revision as of 00:19, 21 November 2007
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THE BINDING DOMAIN OF SKN-1 IN COMPLEX WITH DNA: A NEW DNA-BINDING MOTIF
Overview
The DNA-binding domain of Skn-1, a developmental transcription factor that, specifies mesoderm in C. elegans, is shown by X-ray crystallography to, have a novel fold in which a compact, monomeric, four-helix unit organizes, two DNA-contact elements. At the C-terminus, a helix extends from the, domain to occupy the major groove of DNA in a manner similar to bZip, proteins. Skn-1, however, lacks the leucine zipper found in all bZips., Additional contacts with the DNA are made by a short basic segment at the, N-terminus of the domain, reminiscent of the 'homeodomain arm'.
About this Structure
1SKN is a Single protein structure of sequence from Caenorhabditis elegans with LDA as ligand. Full crystallographic information is available from OCA.
Reference
A new DNA-binding motif in the Skn-1 binding domain-DNA complex., Rupert PB, Daughdrill GW, Bowerman B, Matthews BW, Nat Struct Biol. 1998 Jun;5(6):484-91. PMID:9628487
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