1ssk
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(New page: 200px<br /><applet load="1ssk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ssk" /> '''Structure of the N-terminal RNA-binding Doma...)
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Revision as of 00:30, 21 November 2007
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Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein
Overview
The severe acute respiratory syndrome (SARS) virus belongs to the, Coronaviridea family of viruses. Its virion encodes several proteins, including a replicase and four structural proteins. Here we describe the, three-dimensional structure of the N-terminal domain of the SARS, coronavirus (CoV) nucleocapsid protein. The protein consists of a, five-stranded beta sheet with a folding topology distinct from other, RNA-binding proteins. Single-stranded RNAs bind to the protein surface at, the junction between a flexible, positively charged beta hairpin and the, core structure. NMR-based screening was used to identify low molecular, weight compounds that bind to this site.
About this Structure
1SSK is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.
Reference
Structure of the N-terminal RNA-binding domain of the SARS CoV nucleocapsid protein., Huang Q, Yu L, Petros AM, Gunasekera A, Liu Z, Xu N, Hajduk P, Mack J, Fesik SW, Olejniczak ET, Biochemistry. 2004 May 25;43(20):6059-63. PMID:15147189
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