1sui
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(New page: 200px<br /><applet load="1sui" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sui, resolution 2.70Å" /> '''Alfalfa caffeoyl coe...)
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Revision as of 00:33, 21 November 2007
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Alfalfa caffeoyl coenzyme A 3-O-methyltransferase
Overview
Caffeoyl coenzyme A 3-O-methyltransferases (CCoAOMTs) are, S-adenosyl-l-methionine-dependent O-methyltransferases (OMTs) involved in, lignin biosynthesis. Plant CCoAOMTs belong to a distinct family of OMTs, more closely related to the mammalian catechol OMTs than to other plant, OMTs. The crystal structure of alfalfa (Medicago sativa) CCoAOMT in, complex with the reaction products S-adenosine-l-homocysteine and, feruloyl/sinapoyl CoAs presented here belong to a structurally and, mechanistically distinct family of plant small molecule OMTs. These, structures provide a new understanding of the substrate preferences and, the catalytic mechanism accompanying CCoAOMT-mediated O-methylation of, CoA-linked phenylpropanoid substrates.
About this Structure
1SUI is a Single protein structure of sequence from Medicago sativa with CA, SAH and FRE as ligands. Active as Caffeoyl-CoA O-methyltransferase, with EC number 2.1.1.104 Full crystallographic information is available from OCA.
Reference
Crystal structures of alfalfa caffeoyl coenzyme A 3-O-methyltransferase., Ferrer JL, Zubieta C, Dixon RA, Noel JP, Plant Physiol. 2005 Mar;137(3):1009-17. Epub 2005 Feb 25. PMID:15734921
Page seeded by OCA on Wed Nov 21 02:40:55 2007
