1sum

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Revision as of 00:33, 21 November 2007

Image:1sum.gif

1sum, resolution 2.00Å

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Crystal structure of a hypothetical protein at 2.0 A resolution

Overview

PhoU proteins are known to play a role in the regulation of phosphate, uptake. In Thermotoga maritima, two PhoU homologues have been identified, bioinformatically. Here we report the crystal structure of one of the PhoU, homologues at 2.0 A resolution. The structure of the PhoU protein, homologue contains a highly symmetric new structural fold composed of two, repeats of a three-helix bundle. The structure unexpectedly revealed a, trinuclear and a tetranuclear iron cluster that were found to be bound on, the surface. Each of the two multinuclear iron clusters is coordinated by, a conserved E(D)XXXD motif pair. Our structure reveals a new class of, metalloprotein containing multinuclear iron clusters. The possible, functional implication based on the structure are discussed.

About this Structure

1SUM is a Single protein structure of sequence from Thermotoga maritima with FE, NI, CA and PO3 as ligands. Full crystallographic information is available from OCA.

Reference

Crystal structure of a PhoU protein homologue: a new class of metalloprotein containing multinuclear iron clusters., Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH, J Biol Chem. 2005 Apr 22;280(16):15960-6. Epub 2005 Feb 16. PMID:15716271

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