1svb
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(New page: 200px<br /><applet load="1svb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1svb, resolution 1.9Å" /> '''ENVELOPE GLYCOPROTEIN...)
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Revision as of 00:35, 21 November 2007
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ENVELOPE GLYCOPROTEIN FROM TICK-BORNE ENCEPHALITIS VIRUS
Overview
The crystallographically determined structure of a soluble fragment from, the major envelope protein of a flavivirus reveals an unusual, architecture. The flat, elongated dimer extends in a direction that would, be parallel to the viral membrane. Residues that influence binding of, monoclonal antibodies lie on the outward-facing surface of the protein., The clustering of mutations that affect virulence in various flaviviruses, indicates a possible receptor binding site and, together with other, mutational and biochemical data, suggests a picture for the, fusion-activating, conformational change triggered by low pH.
About this Structure
1SVB is a Single protein structure of sequence from Tick-borne encephalitis virus with NAG as ligand. Full crystallographic information is available from OCA.
Reference
The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution., Rey FA, Heinz FX, Mandl C, Kunz C, Harrison SC, Nature. 1995 May 25;375(6529):291-8. PMID:7753193
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