3dbs
From Proteopedia
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{{STRUCTURE_3dbs| PDB=3dbs | SCENE= }} | {{STRUCTURE_3dbs| PDB=3dbs | SCENE= }} | ||
| - | + | ===Structure of PI3K gamma in complex with GDC0941=== | |
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==About this Structure== | ==About this Structure== | ||
3DBS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBS OCA]. | 3DBS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBS OCA]. | ||
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| + | ==Reference== | ||
| + | The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin -4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer ., Folkes AJ, Ahmadi K, Alderton WK, Alix S, Baker SJ, Box G, Chuckowree IS, Clarke PA, Depledge P, Eccles SA, Friedman LS, Hayes A, Hancox TC, Kugendradas A, Lensun L, Moore P, Olivero AG, Pang J, Patel S, Pergl-Wilson GH, Raynaud FI, Robson A, Saghir N, Salphati L, Sohal S, Ultsch MH, Valenti M, Wallweber HJ, Wan NC, Wiesmann C, Workman P, Zhyvoloup A, Zvelebil MJ, Shuttleworth SJ, J Med Chem. 2008 Sep 25;51(18):5522-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18754654 18754654] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]] | [[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]] | ||
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[[Category: Pi3k gamma]] | [[Category: Pi3k gamma]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
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Revision as of 07:05, 8 October 2008
Structure of PI3K gamma in complex with GDC0941
Template:ABSTRACT PUBMED 18754654
About this Structure
3DBS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin -4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer ., Folkes AJ, Ahmadi K, Alderton WK, Alix S, Baker SJ, Box G, Chuckowree IS, Clarke PA, Depledge P, Eccles SA, Friedman LS, Hayes A, Hancox TC, Kugendradas A, Lensun L, Moore P, Olivero AG, Pang J, Patel S, Pergl-Wilson GH, Raynaud FI, Robson A, Saghir N, Salphati L, Sohal S, Ultsch MH, Valenti M, Wallweber HJ, Wan NC, Wiesmann C, Workman P, Zhyvoloup A, Zvelebil MJ, Shuttleworth SJ, J Med Chem. 2008 Sep 25;51(18):5522-32. PMID:18754654
Page seeded by OCA on Wed Oct 8 09:05:10 2008
