This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1szh
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="1szh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1szh, resolution 1.50Å" /> '''Crystal Structure of...)
Next diff →
Revision as of 00:45, 21 November 2007
|
Crystal Structure of C. elegans HER-1
Overview
HER-1 is a secreted protein that promotes male development in the nematode, Caenorhabditis elegans. HER-1 inhibits the function of TRA-2A, a multipass, integral membrane protein thought to serve as its receptor. We report here, the 1.5-A crystal structure of HER-1. The structure was solved by the, multiwavelength anomalous diffraction method by using, selenomethionyl-substituted HER-1 produced in Chinese hamster ovary cells., The HER-1 structure consists of two all-helical domains and is not closely, homologous to any known structure. Sites of amino acid substitutions known, to impair HER-1 function were mapped on the HER-1 structure and classified, according to the likely mechanism by which they affect HER-1 activity. A, subset of these and other amino acid substitutions on the HER-1 surface, were assayed for their ability to disrupt interactions between HER-1 and, TRA-2A-expressing cells, and a localized region on the HER-1 surface, important for mediating this interaction was identified.
About this Structure
1SZH is a Single protein structure of sequence from Caenorhabditis elegans with ACT as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A., Hamaoka BY, Dann CE 3rd, Geisbrecht BV, Leahy DJ, Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11673-8. Epub 2004 Aug 2. PMID:15289613
Page seeded by OCA on Wed Nov 21 02:52:21 2007
