1szw
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(New page: 200px<br /><applet load="1szw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1szw, resolution 2.00Å" /> '''Crystal structure of...)
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Revision as of 00:45, 21 November 2007
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Crystal structure of E. coli tRNA pseudouridine synthase TruD
Overview
Pseudouridine synthases catalyse the isomerisation of uridine to, pseudouridine in structural RNA. The pseudouridine synthase TruD, that, modifies U13 in tRNA, belongs to a recently identified and large family of, pseudouridine synthases present in all kingdoms of life. We report here, the crystal structure of Escherichia coli TruD at 2.0 A resolution. The, structure reveals an overall V-shaped molecule with an RNA-binding cleft, formed between two domains: a catalytic domain and an insertion domain., The catalytic domain has a fold similar to that of the catalytic domains, of previously characterised pseudouridine synthases, whereas the insertion, domain displays a novel fold.
About this Structure
1SZW is a Single protein structure of sequence from Escherichia coli. Active as Pseudouridylate synthase, with EC number 4.2.1.70 Full crystallographic information is available from OCA.
Reference
X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold., Ericsson UB, Nordlund P, Hallberg BM, FEBS Lett. 2004 May 7;565(1-3):59-64. PMID:15135053
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