1t2s

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Revision as of 00:49, 21 November 2007

Image:1t2s.gif

1t2s

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Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain

Overview

We describe the solution structures of the Argonaute2 PAZ domain bound to, RNA and DNA oligonucleotides. The structures reveal a unique mode of, single-stranded nucleic acid binding in which the two 3'-terminal, nucleotides are buried in a hydrophobic cleft. We propose that the PAZ, domain contributes to the specific recognition of siRNAs by providing a, binding pocket for their characteristic two-nucleotide 3' overhangs.

About this Structure

1T2S is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain., Lingel A, Simon B, Izaurralde E, Sattler M, Nat Struct Mol Biol. 2004 Jun;11(6):576-7. Epub 2004 May 23. PMID:15156196

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