User:Wayne Decatur/Sandbox
From Proteopedia
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{{STRUCTURE_1r9f | PDB= 1r9f | SCENE= }} | {{STRUCTURE_1r9f | PDB= 1r9f | SCENE= }} | ||
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| + | <!-- | ||
| + | The line below this paragraph, containing "STRUCTURE_1eve", creates the "Structure Box" on the page. | ||
| + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| + | or leave the SCENE parameter empty for the default display. | ||
| + | --> | ||
| + | {{STRUCTURE_1eve | PDB= 1eve | SCENE=Main_Page/E2020_in_ache_spinning/1 }} | ||
| + | The collaborative, 3D encyclopedia of proteins and other molecules. | ||
| + | ===<span style="color:green">Green</span> links change the 3D image!=== | ||
| + | <big>''Here's an excerpt from one of our pages ([[1eve]]):''</big> | ||
| + | |||
| + | The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a '''<scene name='1eve/E2020_close_up_with_84_279/12'>unique orientation</scene>''' along the active-site gorge, extending from the anionic subsite ('''<scene name='1eve/E2020_close_up_with_84lbld/6'>W84</scene>''') of the active site, at the bottom, to the peripheral anionic site ('''<scene name='1eve/E2020_close_up_with_84_279lbld/4'>near W279</scene>'''), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only '''<scene name='1eve/E20_interactionshown/7'>indirectly via solvent molecules</scene>'''. | ||
| + | ---- | ||
Revision as of 06:25, 18 October 2008
Here is a schematic illustration of the two strands of this silencing RNA (siRNA):
5'-pCGUACGCGUCACGCGUACGUU-OH-3'
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3'-OH-UUGCAUGCGCACUGCGCAUGCp-5'
Template:STRUCTURE 1r9f
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| 1eve, resolution 2.50Å () | |||||||||
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| Ligands: | , | ||||||||
| Activity: | Acetylcholinesterase, with EC number 3.1.1.7 | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
The collaborative, 3D encyclopedia of proteins and other molecules.
Green links change the 3D image!
Here's an excerpt from one of our pages (1eve):
The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from Torpedo california) complex shows that E2020 has a along the active-site gorge, extending from the anionic subsite () of the active site, at the bottom, to the peripheral anionic site (), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only .
