1tnd

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(New page: 200px<br /><applet load="1tnd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tnd, resolution 2.2&Aring;" /> '''THE 2.2 ANGSTROMS CRY...)
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Revision as of 01:18, 21 November 2007

Image:1tnd.gif

1tnd, resolution 2.2Å

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THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S

Overview

The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP, gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft, between a domain structurally homologous to small GTPases and a helical, domain unique to heterotrimeric G proteins. The structure, when combined, with biochemical and genetic studies, suggests: how an activated receptor, might open this cleft to allow nucleotide exchange; a mechanism for, GTP-induced changes in effector and receptor binding surfaces; and a, mechanism for GTPase activity not evident from previous data.

About this Structure

1TND is a Single protein structure of sequence from Bos taurus with MG, CAC and GSP as ligands. Full crystallographic information is available from OCA.

Reference

The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S., Noel JP, Hamm HE, Sigler PB, Nature. 1993 Dec 16;366(6456):654-63. PMID:8259210

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