1tro
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="1tro" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tro, resolution 1.900Å" /> '''CRYSTAL STRUCTURE O...)
Next diff →
Revision as of 01:25, 21 November 2007
|
CRYSTAL STRUCTURE OF TRP REPRESSOR OPERATOR COMPLEX AT ATOMIC RESOLUTION
Overview
The crystal structure of the trp repressor/operator complex shows an, extensive contact surface, including 24 direct and 6 solvent-mediated, hydrogen bonds to the phosphate groups of the DNA. There are no direct, hydrogen bonds or non-polar contacts to the bases that can explain the, repressor's specificity for the operator sequence. Rather, the sequence, seems to be recognized indirectly through its effects on the geometry of, the phosphate backbone, which in turn permits the formation of a stable, interface. Water-mediated polar contacts to the bases also appear to, contribute part of the specificity.
About this Structure
1TRO is a Single protein structure of sequence from Escherichia coli with TRP as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of trp repressor/operator complex at atomic resolution., Otwinowski Z, Schevitz RW, Zhang RG, Lawson CL, Joachimiak A, Marmorstein RQ, Luisi BF, Sigler PB, Nature. 1988 Sep 22;335(6188):321-9. PMID:3419502
Page seeded by OCA on Wed Nov 21 03:32:35 2007
