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2bli

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(New page: 200px<br /> <applet load="2bli" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bli, resolution 1.7&Aring;" /> '''L29W MB DEOXY'''<br ...)
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Revision as of 19:06, 29 October 2007

Image:2bli.gif

2bli, resolution 1.7Å

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L29W MB DEOXY

Overview

We have determined eight X-ray structures of myoglobin mutant L29W at, various experimental conditions. In addition, infrared spectroscopic, experiments are presented, which are discussed in the light of the X-ray, structures. Two distinct conformations of the CO-ligated protein were, identified, giving rise to two stretching bands of heme-bound CO. If L29W, MbCO crystals are illuminated around 180 K, a deoxy species is formed. The, CO molecules migrate to the proximal side of the heme and remain trapped, in the so-called Xe1 cavity upon temperature decrease to 105 K. The, structure of this photoproduct is almost identical to the equilibrium, high-temperature deoxy Mb structure. If the temperature is cycled to, increasingly higher values, CO recombination is observed. Three, intermediate ... [(full description)]

About this Structure

2BLI is a [Single protein] structure of sequence from [Physeter catodon] with HEM as [ligand]. Full crystallographic information is available from [OCA].

Reference

Ligand migration and protein fluctuations in myoglobin mutant L29W., Nienhaus K, Ostermann A, Nienhaus GU, Parak FG, Schmidt M, Biochemistry. 2005 Apr 5;44(13):5095-105. PMID:15794647

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